Tegatrabetan New
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CAS No. | 1227637-23-1 | Cat. No. | BCP32893 |
Name | Tegatrabetan | ||
Synonyms | BC2059; BC-2059; BC 2059;Tegavivint; | ||
SMILES | CC1CC(CN(C1)S(=O)(=O)C2=CC3=C(C=C2)C(=C4C=CC(=CC4=C3N=O)S(=O)(=O)N5CC(CC(C5)C)C)NO)C | ||
Chemical Name | |||
Formula | C28H36N4O6S2 | M. Wt | 588.74 |
Purity | 98% | Storage | Store at 4-8°C |
Description | Tegatrabetan is an orally bioavailable and potent β-catenin inhibitor. BC2059 potently induces apoptosis as a single agent and in combination with bortezomib in multiple myeloma. BC2059 induced apoptosis in 10/10 genetically heterogeneous human myeloma cell lines (HMCL) treated with dosages ranging from 50-500nM. |
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