CL2A-SN-38 New
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Publications Citing of Biochempartner's CL2A-SN-38
| CAS No. | 1279680-68-0 | Cat. No. | BCP32728 |
| Name | CL2A-SN-38 | ||
| Synonyms | |||
| SMILES | O=C(O[C@](C1=C(CO2)C(N3CC4=C(CC)C5=CC(O)=CC=C5N=C4C3=C1)=O)(CC)C2=O)OCC6=CC=C(NC([C@H](CCCCN)NC(COCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCN7N=NC(CNC(C8CCC(CN9C(C=CC9=O)=O)CC8)=O)=C7)=O)=O)=O)C=C6 | ||
| Chemical Name | |||
| Formula | C73H97N11O22 | M. Wt | 1480.61 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | CL2A-SN-38 is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A is a nonclaevable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. | ||
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