Resiquimod HCl New
Data Sheet
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| CAS No. | 1313757-36-6 | Cat. No. | BCP38086 |
| Name | Resiquimod HCl | ||
| Synonyms | R-848; R 848; R848; S 28463; S-28463; S28463; VML-600; VML600; VML 600; | ||
| SMILES | CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | ||
| Chemical Name | |||
| Formula | C17H23ClN4O2 | M. Wt | 350.85 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Resiquimod is a n imidazoquinolinamine Toll-like receptor (TLR) agonist with potential immunostimulatory activity. Resiquimod binds to and activates TLRs 7 and 8, mainly on dendritic cells (DCs), macrophages, and B-lymphocytes, which results in the activation of the TLR signaling pathway and nuclear translocation of the transcription activator NF-kB another transcription factors; subsequently, the production of cytokines, especially interferon-alpha (INF-a), increases, enhancing T-helper 1 (Th1) immune responses. In addition, topical application of resiquimod appears to activate Langerhans cells, which may result in enhanced activation of T-lymphocytes. | ||
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