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PRT062607 Chemical Structure

PRT062607

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP06469CAS No. ：1370261-96-3Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1370261-96-3 Cat. No. BCP06469
Name PRT062607
Synonyms P5 0515;P50515;PRT-062607;PRT 062607;PRT062607;
SMILES
Chemical Name
Formula C19H23N9O M. Wt 393.45
Purity 98% Storage Store at 4-8°C
Description PRT062607(P505-15) anti-SYK activity is at least 80-fold greater than its affinity for other kinases. at least 80-fold greater than its affinity for other kinases. PRT062607 potently inhibits B cell antigen receptor-mediated B cell signaling and activation (IC50 0.27 and 0.28 μM, respectively) and Fcε receptor 1-mediated basophil degranulation (IC50 0.15 μM).PRT062607 inhibits BCR-dependent secretion of the chemokines CCL3 and CCL4 by CLL cells, and leukemia cell migration toward the tissue homing chemokines CXCL12, CXCL13, and beneath stromal cells. PRT062607 furthermore inhibits Syk and extracellular signal-regulated kinase phosphorylation after BCR triggering.
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