Ambroxol hydrochloride
Data Sheet
For research use only. Not for human use.
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| CAS No. | 23828-92-4 | Cat. No. | BCP04490 |
| Name | Ambroxol hydrochloride | ||
| Synonyms | Ambroxol HCl;NA-872; NA872; NA 872; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C13H19Br2ClN2O | M. Wt | 414.56 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Ambroxol inhibits Na+ channels in sensory neurons. The potency for tonic block of TTX-r channels is relatively high. Ambroxol affects the Na+ current kinetics of TTX-r and TTX-s channels differently. In CNaIIA cells, the compound behaves like a charged local anesthetic: the block is dependent on stimulus number and increases with higher frequencies in a train of depolarizing stimuli. In CNaIIA cells, ambroxol inhibits inactivated channels 5.5-fold more potently than resting channels. The corresponding factor for TTX-r channels is only 3.3.Ambroxol inhibits the release of histamine, leukotrienes and cytokines from human leukocytes and mast cells. | ||
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