MK-5172 sodium salt
Data Sheet
For research use only. Not for human use.
Get Quotation Now* Required Fields.
Please complete the form below and you will get the price list in 1 minute.
* Required Fields.
Please complete the form below and we will contact you shortly.
* Required Fields.
Please complete the form below and we will contact you shortly.
| CAS No. | 1425038-27-2 | Cat. No. | BCP13442 |
| Name | MK-5172 sodium salt | ||
| Synonyms | MK 5172 sodium salt;MK5172 sodium salt; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C38H50N6NaO9S+ | M. Wt | 789.89 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | in vitro: In biochemical assays, MK-5172 was effective against a panel of major genotypes and variants engineered with common resistant mutations observed in clinical studies with other NS3/4a protease inhibitors. In the replicon assay, MK-5172 demonstrated subnanomolar to low-nanomolar EC50s against genotypes 1a, 1b, and 2a . in vivo: In rats, MK-5172 showed a plasma clearance of 28 ml/min/kg and plasma half-life of 1.4 hr. When dosed p.o. at 5 mg/kg, the plasma exposure of MK-5172 was good with an AUC of 0.7 uM.hr. The liver exposure of the compound was quite good (23 uM at 4 hr), and MK-5172 remained in liver 24 hr after a single p.o. 5 mg/kg dose. At 24 hr, the liver concentration of MK-5172 was 0.2 uM, which was over 25-fold higher than the IC50 in the replicon assay with 50% NHS. When dosed to dogs, MK-5172 showed low clearance of 5 ml/min/kg and a 3 hr half-life after i.v. 2 mg/kg dosing and had good plasma exposure (AUC=0.4 uM.hr) after a p.o. 1 mg/kg dose . | ||
Recommend Products
More >
-
-
GSK2200150A
Cat. No.：BCP29624
No.：1443138-53-1
Product Details -
-
-
Sulconazole nitrate
Cat. No.：BCP25551
No.：61318-91-0
Product Details -
Erythromycylamine
Cat. No.：BCP20223
No.：26116-56-3
Product Details -
-
Ceftobiprole trifluoroacetate
Cat. No.：BCP19977
No.：1031275-04-3
Product Details -
-
Ceftobiprole medocaril
Cat. No.：BCP18211
No.：376653-43-9
Product Details -
Ceftobiprole
Cat. No.：BCP18210
No.：209467-52-7
Product Details -
Squalamine lactate
Cat. No.：BCP24210
No.：320725-47-1
Product Details -
Finafloxacin
Cat. No.：BCP23882
No.：209342-40-5
Product Details -
Fluralaner
Cat. No.：BCP23785
No.：864731-61-3
Product Details -
Ceftizoxime
Cat. No.：BCP12173
No.：68401-81-0
Product Details -
Sulfamethazine
Cat. No.：BCP28439
No.：57-68-1
Product Details -
Ceftizoxime alapivoxil
Cat. No.：BCP28430
No.：135821-54-4
Product Details -
Ceftizoxime sodium
Cat. No.：BCP11978
No.：68401-82-1
Product Details -
Pneumocandin B0
Cat. No.：BCP09296
No.：135575-42-7
Product Details -
Rilpivirine
Cat. No.：BCP03563
No.：500287-72-9
Product Details
Tags:MK-5172 sodium salt supplier,MK-5172 sodium salt purchase,MK-5172 sodium salt manufacturer,MK-5172 sodium salt distributor,MK-5172 sodium salt cost,MK-5172 sodium salt buy,MK-5172 sodium salt for sale