Hexamethyleneamiloride New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1428-95-1 | Cat. No. | BCP41883 |
| Name | Hexamethyleneamiloride | ||
| Synonyms | 5-(N,N-Hexamethylene)amiloride; HMA; | ||
| SMILES | C1CCCN(CC1)C2=NC(=C(N=C2Cl)C(=O)N=C(N)N)N | ||
| Chemical Name | |||
| Formula | C12H18ClN7O | M. Wt | 311.77 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Hexamethyleneamiloride derives from an amiloride and is a potent Na+/H+ exchanger inhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells. It is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3.91 μM and 1.34 μM, respectively. | ||
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