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Brimapitide Chemical Structure

Brimapitide

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP46470CAS No. ：1445179-97-4Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1445179-97-4 Cat. No. BCP46470
Name Brimapitide
Synonyms D-JNKI-1;L-JNKi1;
SMILES
Chemical Name
Formula C164H286N66O40 M. Wt 3822.4
Purity 98% Storage Store at 4-8°C
Description Brimapitide is a protease resistant, potent inhibitor specific for JNK (JNK1, JNK2 and JNK3). L-JNKi 1 does not directly affect kinase activity e.g. by competing with the ATP-binding site of the protein kinase, rather L-JNKi1 inhibits the interaction between JNK and its substrate, resulting in a JNK K.O. phenotype. In contrast to pure diffusion they are actively transported into cells, where they remain until their proteolytic degradation. The c-Jun N-terminal kinases (JNK1, 2, 3), members of the mitogen-activated protein kinase (MAPK) superfamily, are activated by a wide variety of extracellular stimuli such as inflammatory cytokines, heat shock and ischemia.
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