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NMS-859 Chemical Structure

NMS-859

Data Sheet For research use only. Not for human use.
Cat. No. :BCP19908CAS No. :1449236-96-7Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1449236-96-7 Cat. No. BCP19908
Name NMS-859
Synonyms NMS859;NMS 859;
SMILES
Chemical Name
Formula C15H12ClN3O3S M. Wt 349.79
Purity 98% Storage Store at 4-8°C
Description NMS-859 is very selective (IC50 >10 μM) against all of the AAA ATPases, HSP90 or the 53 kinases tested. NMS-859 was active in a cell proliferation assay, with IC50 values of 3.5 μM and 3.0 μM in HCT116 and HeLa cell lines, respectively. NMS-859 covalently modifies VCP on the active site Cys522 and blocks ATP binding. NMS-859 provided critical validation of VCP as a cancer target, and it raises the possibility that targeting VCP might prevent proteasome inhibitor–resistant tumors from escaping through the aggresome-autophagy pathways and cause them to collapse under the high load of unfolded proteins.
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