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CAS No. | 1464151-33-4 | Cat. No. | BCP30906 |
Name | ETC-206 | ||
Synonyms | ETC 206; ETC206;ETC-1907206; | ||
SMILES | C1COCCN1C(=O)C2=CC=C(C=C2)C3=CN4C(=NC=C4C5=CC=C(C=C5)C#N)C=C3 | ||
Chemical Name | |||
Formula | C25H20N4O2 | M. Wt | 408.46 |
Purity | 98% | Storage | Store at 4-8°C |
Description | ETC-206 is a selective MNK1/2 inhibitor with IC50 = 64 nM (for MNK1) and IC50 = 84 nM (for MNK2). ETC-206 in combination with dasatinib prevents BC-CML LSC self-renewal in vitro and enhances dasatinib antitumor activity in vivo. |
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