Pralatrexate New
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| CAS No. | 146464-95-1 | Cat. No. | BCP02025 |
| Name | Pralatrexate | ||
| Synonyms | Folotyn;10-Propargyl-10-deazaaminopterin; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C23H23N7O5 | M. Wt | 477.47 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Pralatrexate is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively enters cells expressing RFC-1; intracellularly, this agent is highly polyglutamylated and competes for the folate binding site of DHFR, blocking tetrahydrofolate synthesis, which may result in depletion of nucleotide precursors; inhibition of DNA, RNA and protein synthesis; and apoptotic tumor cell death. | ||
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