AZ191
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1594092-37-1 | Cat. No. | BCP12820 |
| Name | AZ191 | ||
| Synonyms | AZ-191;AZ 191; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C24H27N7O | M. Wt | 429.52 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Using in vitro kinase assays, phospho-specific immunoblot analysis and MS in conjunction with AZ191 we now show that DYRK1B phosphorylates CCND1 at Thr(286), not Thr(288), in vitro and in cells. In HEK (human embryonic kidney)-293 and PANC-1 cells (which exhibit DYRK1B amplification) DYRK1B drives Thr(286) phosphorylation and proteasome-dependent turnover of CCND1 and this is abolished by AZ191 or DYRK1B RNAi, but not by GSK3β inhibitors or GSK3β RNAi. | ||
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