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AZ191
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CAS No. | 1594092-37-1 | Cat. No. | BCP12820 |
Name | AZ191 | ||
Synonyms | AZ-191;AZ 191; | ||
SMILES | |||
Chemical Name | |||
Formula | C24H27N7O | M. Wt | 429.52 |
Purity | 98% | Storage | Store at 4-8°C |
Description | Using in vitro kinase assays, phospho-specific immunoblot analysis and MS in conjunction with AZ191 we now show that DYRK1B phosphorylates CCND1 at Thr(286), not Thr(288), in vitro and in cells. In HEK (human embryonic kidney)-293 and PANC-1 cells (which exhibit DYRK1B amplification) DYRK1B drives Thr(286) phosphorylation and proteasome-dependent turnover of CCND1 and this is abolished by AZ191 or DYRK1B RNAi, but not by GSK3β inhibitors or GSK3β RNAi. |
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