GNF4877 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 2041073-22-5 | Cat. No. | BCP31624 |
| Name | GNF4877 | ||
| Synonyms | GNF 4877;GNF-4877; | ||
| SMILES | O=C([C@H]1CN(C2=C(NC(C3=NC(C4=CC(OC(C)C)=CC=C4F)=CN=C3N)=O)C=NC=C2)CCC1)O | ||
| Chemical Name | |||
| Formula | C25H27FN6O4 | M. Wt | 494.52 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6 nM and 16 nM, respectively, which leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation (EC50 of 0.66 μM for mouse β (R7T1) cells). | ||
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