JNJ-47117096
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1610586-62-3 | Cat. No. | BCP26188 |
| Name | JNJ-47117096 | ||
| Synonyms | JNJ47117096; JNJ 47117096;MELK-T1; MELK-T 1; MELK-T-1; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C21H22N4O2 | M. Wt | 362.43 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | MELK-T1 is a potent and selective inhibitor of protein kinase MELK. MELK-T1 decreases DNA-damage tolerance in proliferating cancer cells. MELK-T1 triggered a rapid and proteasome-dependent degradation of the MELK protein. Treatment of MCF-7 breast adenocarcinoma cells with MELK-T1 induced the accumulation of stalled replication forks and double-strand breaks that culminated in a replicative senescence phenotype. MELK-T1 induced a strong phosphorylation of p53, a prolonged upregulation of p21 and a downregulation of FOXM1 target genes. | ||
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