Valganciclovir hydrochloride
Data Sheet
For research use only. Not for human use.
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| CAS No. | 175865-59-5 | Cat. No. | BCP08146 |
| Name | Valganciclovir hydrochloride | ||
| Synonyms | |||
| SMILES | |||
| Chemical Name | |||
| Formula | C14H23ClN6O5 | M. Wt | 390.83 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | in vitro: In cell culture model systems using Caco-2 cells for PEPT1 and SKPT cells for PEPT2, valganciclovir inhibited glycylsarcosine transport mediated by PEPT1 and PEPT2 with K(i) values (inhibition constant) of 1.68+/-0.30 and 0.043+/- 0.005 mM, respectively. The inhibition by valganciclovir was competitive in both cases . in vivo: 37 patients were enrolled; 19 patients received treatment with VGV and 18 patients received treatment with GCV. The VGV was not inferior in efficacy to GCV as pre-emptive therapy, with rates of viral clearance at 28 days of 89.5% and 83%, respectively (P-value for non-inferiority = 0.030). Toxicities were similar between the 2 arms. No patients developed CMV disease [2]. Patients being treated with an alemtuzumab-containing regimen received prophylaxis with either valaciclovir 500 mg orally daily orvalganciclovir 450 mg orally twice daily. None of the 20 patients randomized to valganciclovir experienced CMV reactivation (P = .004) . | ||
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