Capromorelin Tartrate New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 193273-69-7 | Cat. No. | BCP15666 |
| Name | Capromorelin Tartrate | ||
| Synonyms | CP 424391-18; CP-424,391-18; CP-424391 Tartrate; | ||
| SMILES | CC(C)(C(=O)NC(COCC1=CC=CC=C1)C(=O)N2CCC3=NN(C(=O)C3(C2)CC4=CC=CC=C4)C)N.C(C(C(=O)O)O)(C(=O)O)O | ||
| Chemical Name | |||
| Formula | C32H41N5O10 | M. Wt | 655.71 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Capromorelin Tartrate is an orally active, potent growth hormone secretagogue receptor (GHSR) agonist, with Ki of 7 nM for hGHS-R1a.Capromorelin, also known as CP-424,391, is a growth hormone secretagogue and ghrelin mimetic ( hGHS-R1a K(i)=7 nM, rat pituicyte EC(50)=3 nM). Initial studies have shown the drug to directly raise insulin growth factor 1 (IGF-1) and growth hormone levels. Capromorelin showed enhanced intestinal absorption in rodent models and exhibited superior pharmacokinetic properties, including high bioavailabilities in two animal species [F(rat)=65%, F(dog)=44%]. This short-duration GHS was orally active in canine models and was selected as a development candidate for the treatment of musculoskeletal frailty in elderly adults. | ||
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