Lonafarnib

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP07027CAS No. ：193275-84-2Purity：98%

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CAS No.	193275-84-2	Cat. No.	BCP07027
Name	Lonafarnib
Synonyms	Sarasar;Sch 66336;Sch-66336;Sch66336;
SMILES
Chemical Name
Formula	C27H31Br2ClN4O2	M. Wt	638.82
Purity	98%	Storage	Store at 4-8°C
Description	SCH66336 at concentration ranging from 0.1 μM to 8 μM suppress growth and induce apoptosis of human head and neck squamous carcinoma cells (HNSCC) in a dose and time dependent manner. SCH66336 (8 μM) suppresses protein kinase B/Akt activity as well as the phosphorylation of the Akt substrates glycogen synthase kinase (GSK)-3β, forkhead transcription factor, and BAD in SqCC/Y1 cells. SCH66336 demonstrate variable antiproliferative effects against the cell lines, with IC50 ranging from 0.6 μM to 32.3 μM. Lonafarnib induces a CCAAT/enhancer-binding protein homologous protein (CHOP)-dependent transactivation of the DR5 promoter, thus induces CHOP-dependent DR5 up-regulation. Lonafarnib (< 10 μM) activates caspase-8 and its downstream caspases, thus induces caspase-8-dependent apoptosis in H1792 cells. Lonafarnib (5 μM) up-regulate DR5 expression, increase cell-surface DR5 distribution, and enhance tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in H1792 cells.