NSC 133723 Hot Discount
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| CAS No. | 19741-14-1 | Cat. No. | BCP02884 |
| Name | NSC 133723 | ||
| Synonyms | NSC131463;DAMPA;NSC-131463;Deoxyaminopteroic acid;Methotrexate Impurity E;4-Amino-4-deoxy-10-methylpteroic acid; | ||
| SMILES | O=C(O)C1=CC=C(N(CC2=NC3=C(N)N=C(N)N=C3N=C2)C)C=C1 | ||
| Chemical Name | |||
| Formula | C15H15N7O2 | M. Wt | 325.33 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | NSC 131463 is a minor metabolite of methotrexate. It inhibited L1210 cell proliferation in culture (IC50 = 0.3 μM), and prolonged the survival of L1210 leukemic mice (98% increase in lifespan at 120 mg/kg, qdx9). Studies on the interaction of mAPA-HCysA with partially purified mouse liver folyl polyglutamate synthetase revealed that mAPA-HCysA was not a substrate. Hence, the increased dose of mAPA-HCysA required to inhibit tumor growth in vitro and in vivo relative to methotrexate may reflect, in part, the inability of this compound to form non-effluxing polyglutamates. | ||
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