GW311616
Data Sheet
For research use only. Not for human use.
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| CAS No. | 198062-54-3 | Cat. No. | BCP11029 |
| Name | GW311616 | ||
| Synonyms | GW-311616;GW 311616; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C19H32ClN3O4S | M. Wt | 433.99 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | The HNE inhibitor GW311616A is selective over other human serine proteases (IC50 values >100 uM for trypsin, cathepsin G, and plasmin, >3 mM for chymotrypsin and tissue plasminogen activator). Acetylcholinesterase is not inhibited by GW311616A at 100 uM.GW311616A is more potent than thetrifluoromethylketone inhibitor ZD8321 (Ki=13 nM). GW311616A is orallybioavailable in rat, dog (Table 4) and hamster despite moderate to high plasma clearance, which indicates that clearance is predominantly extrahepatic. | ||
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