Dabigatran etexilate
Data Sheet
For research use only. Not for human use.
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| CAS No. | 211915-06-9 | Cat. No. | BCP02864 |
| Name | Dabigatran etexilate | ||
| Synonyms | Prazaxa;BIBR 1048;BIBR-1048;BIBR1048; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C34H41N7O5 | M. Wt | 627.73 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Dabigatran selectively and reversibly inhibits human thrombin (Ki: 4.5 nM) as well as thrombin-induced platelet aggregation (IC50: 10 nM), while showing no inhibitory effect on other platelet-stimulating agents. Dabigatran selectively and reversibly inhibits human thrombin (Ki: 4.5 nM) as well as thrombin-induced platelet aggregation (IC50: 10 nM), while showing no inhibitory effect on other platelet-stimulating agents. Dabigatran inhibits thrombin generation in platelet-poor plasma (PPP) with IC50 of 0.56 μM, measured as the endogenous thrombin potential (ETP). Dabigatran demonstrates concentrationdependent anticoagulant effects in various species in vitro, doubling the activated partial thromboplastin time (aPTT), prothrombin time (PT) and ecarin clotting time (ECT) in human PPP at concentrations of 0.23, 0.83 and 0.18 μM, respectively. | ||
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