AT-527 New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP42710CAS No. ：2241337-84-6Purity：98%

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CAS No.	2241337-84-6	Cat. No.	BCP42710
Name	AT-527
Synonyms	AT527;AT 527;
SMILES
Chemical Name
Formula	C24H35FN7O11PS	M. Wt	679.61
Purity	98%	Storage	Store at 4-8°C
Description	AT-527, a hemisulfate salt of AT-511, a guanosine nucleotide prodrug, is a potent and orally active HCV viral replication inhibitor. AT-527 is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC90=0.47 μM). AT-527 has pangenotypic antiviral activity[1][2][3].AT-511 has pan-genotypic antiviral activities that inhibits HCV genotype 1a (HCV GT1a), HCV GT1b, HCV GT2a, HCV GT3a, HCV GT4a, and HCV GT5a replication with EC50 values of 12.8 nM, 12.5 nM, 9.2 nM, 10.3 nM, 14.7 nM, and 28.5 nM, respectively[1]. In normal human airway epithelial cells, the concentration of AT-511 required to inhibit replication of SARS-CoV-2 by EC90 is 0.47 μM, very similar to its EC90 against HCoV-229E, HCoV-OC43 and SARS-CoV in Huh-7 cells.