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R-1479 Chemical Structure

R-1479

Data Sheet For research use only. Not for human use.
Cat. No. :BCP38817CAS No. :478182-28-4Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 478182-28-4 Cat. No. BCP38817
Name R-1479
Synonyms R 1479; R1479; 4'-Azidocytidine; 4'-c-Azidocytidine;
SMILES C1=CN(C(=O)N=C1N)C2C(C(C(O2)(CO)N=[N+]=[N-])O)O
Chemical Name
Formula C9H12N6O5 M. Wt 284.23
Purity 98% Storage Store at 4-8°C
Description R-1479 is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture. R-1479 is a specific inhibitor of HCV replication in the HCV subgenomic replicon system (IC(50) = 1.28 microM). The corresponding 5'-triphosphate derivative (R1479-TP) is a potent inhibitor of native HCV replicase isolated from replicon cells and of recombinant HCV polymerase (NS5B)-mediated RNA synthesis activity. R1479-TP inhibited RNA synthesis as a CTP-competitive inhibitor with a K(i) of 40 nM.
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