Denibulin New
Data Sheet
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| CAS No. | 284019-34-7 | Cat. No. | BCP21548 |
| Name | Denibulin | ||
| Synonyms | MN029; MN-029; MN 029; | ||
| SMILES | CC(C(=O)NC1=CC=C(C=C1)SC2=CC3=C(C=C2)N=C(N3)NC(=O)OC)N | ||
| Chemical Name | |||
| Formula | C18H19N5O3S | M. Wt | 385.44 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Denibulin is a novel vascular-disrupting agent that reversibly inhibits microtubule assembly, resulting in disruption of the cytoskeleton of tumor vascular endothelial cells. The results of preclinical study demonstrated that MN-029 could cause rapid vascular shutdown in solid tumors, dose-dependent secondary tumor cell killing, and effective enhancement of the antitumor effects of radiation and cisplatin chemotherapy. | ||
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