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Denibulin Chemical Structure

Denibulin

Data Sheet For research use only. Not for human use.
Cat. No. :BCP21548CAS No. :284019-34-7Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 284019-34-7 Cat. No. BCP21548
Name Denibulin
Synonyms MN029; MN-029; MN 029;
SMILES CC(C(=O)NC1=CC=C(C=C1)SC2=CC3=C(C=C2)N=C(N3)NC(=O)OC)N
Chemical Name
Formula C18H19N5O3S M. Wt 385.44
Purity 98% Storage Store at 4-8°C
Description Denibulin is a novel vascular-disrupting agent that reversibly inhibits microtubule assembly, resulting in disruption of the cytoskeleton of tumor vascular endothelial cells. The results of preclinical study demonstrated that MN-029 could cause rapid vascular shutdown in solid tumors, dose-dependent secondary tumor cell killing, and effective enhancement of the antitumor effects of radiation and cisplatin chemotherapy.
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