NPS 2143

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP02421CAS No. ：284035-33-2Purity：98%

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CAS No.	284035-33-2	Cat. No.	BCP02421
Name	NPS 2143
Synonyms	NPS-2143;NPS2143;SB-262470;SB 262470;SB262470;
SMILES
Chemical Name
Formula	C24H25ClN2O2	M. Wt	408.92
Purity	98%	Storage	Store at 4-8°C
Description	NPS 2143 blocks increases in cytoplasmic Ca2+ concentrations with IC50 of 43 nM elicited by activating the Ca2+ receptor in HEK 293 cells expressing the human Ca2+ receptor. NPS 2143 stimulates parathyroid hormone (PTH) secretion from bovine parathyroid cells with EC50 of 41 nM. Moreover, NPS 214 also blocks the inhibitory effects of calcimimetic NPS R-467 on PTH secretion from bovine parathyroid cells and the inhibitory effects of extracellular Ca2+ on isoproterenol-stimulated increases in cyclic AMP formation. In HEK-293 cells transiently expressing hCaSRs, NPS 2143 significantly suppresses the kokumi taste by effectively inhibiting the activity of both GSH (data not shown) and γ-Glu-Val-Gly. A recent study shows that NPS 2143 treatment suppresses low molecular weight fractions of azuki hydrolysate-induced cholecystokinin (CCK) secretion in CaSR-transfected HEK 293 cells.