L-Kynurenine New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 2922-83-0 | Cat. No. | BCP20697 |
| Name | L-Kynurenine | ||
| Synonyms | Kynurenin;Kynurenine; Kynurenine, L-; CCRIS 4425;β-Anthraniloyl-L-alanine; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C10H12N2O3 | M. Wt | 208.21 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Kynurenine is a product of constitutive tryptophan catabolism via tryptophan-2,3-dioxygenase in the liver and human gliomas that is associated with the suppression of antitumor immune responses. At 100 μM, kynurenine inhibits allogeneic T-cell proliferation and increases malignant U87 glioma cell invasion into a collagen matrix.Kynurenine activates the aryl hydrocarbon receptor (AhR) target gene CYP1A1 with an EC50 value of 12.3 μM and binds to AhR with an apparent Kd value of ~4 μM.1 Kynurenine is ultimately metabolized to quinolinic acid, a potent neurotoxin that acts as an NMDA agonist and has been described to be involved in neurodegenerative processes in the brain. | ||
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