L685458
Data Sheet
For research use only. Not for human use.
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| CAS No. | 292632-98-5 | Cat. No. | BCP16163 |
| Name | L685458 | ||
| Synonyms | L-685458;L 685458; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C39H52N4O6 | M. Wt | 672.85 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | L685458 is a potent and selective γ -secretase inhibitor (IC50 = 17 nM) that displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. L685458 also exhibits equal potency for inhibition of A β 40 and A β 42 peptides (IC50 values are 48 and 67 nM respectively in human neuroblastoma cells). Also regulates CXCR4 and VEGFR2 expression through inhibition of Notch signaling in vitro. | ||
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