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cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid Chemical Structure

cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP02273CAS No. ：952578-68-6Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 952578-68-6 Cat. No. BCP02273
Name cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid
Synonyms MK0752;MK 0752;
SMILES
Chemical Name
Formula C21H21ClF2O4S M. Wt 442.9
Purity 98% Storage Store at 4-8°C
Description MK-0752 is identified as a moderately potent γ-secretase inhibitor, which reduces Aβ40 in a dose-dependent manner with an IC50 of 5 nM in human SH-SY5Y cells.In vitro, MK-0752 blocks Notch-intracellular domain (ICD) cleavage and its subsequent nuclear translocation.
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