L002 New
Data Sheet
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| CAS No. | 321695-57-2 | Cat. No. | BCP46453 |
| Name | L002 | ||
| Synonyms | L 002;L-002; p300/CBP Inhibitor VI; NSC 764414; | ||
| SMILES | CC1=CC(=NOS(=O)(=O)C2=CC=C(C=C2)OC)C=C(C1=O)C | ||
| Chemical Name | |||
| Formula | C15H15NO5S | M. Wt | 321.35 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | L-002 is a potent, cell permeable, reversible and specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 μM. L002 binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain, blocks histone acetylation and p53 acetylation, and inhibits STAT3 activation. L002 has the potential for hypertension‐induced cardiac hypertrophy and fibrogenesis treatment. | ||
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