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GW3965 HCl Chemical Structure

GW3965 HCl

Data Sheet For research use only. Not for human use.
Cat. No. :BCP03049CAS No. :405911-17-3Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 405911-17-3 Cat. No. BCP03049
Name GW3965 HCl
Synonyms GW-3965;GW 3965;
SMILES
Chemical Name
Formula C33H31ClF3NO3.HCl M. Wt 618.51
Purity 98% Storage Store at 4-8°C
Description GW3965 recruits the steroid receptor coactivator 1 to human LXRα with EC50 of 125 nM in a cell-free ligand-sensing assay. [1] GW3965 shows a potent antagonistic activity against hLXRα and hLXRβ in cell-based assays with EC50 of 190 nM and 30 nM, respectively. Besides, GW3965 also sows excellent selectivity over other nuclear receptors.In human islets, GW3965 (1 μM) reduces expression of selected pro-inflammatory cytokines including IL-8, monocyte chemotactic protein-1 and tissue factor.
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