RGX-104 HCl

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP29451CAS No. ：610318-03-1Purity：98%

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CAS No.	610318-03-1	Cat. No.	BCP29451
Name	RGX-104 HCl
Synonyms	RGX-104 hydrochloride;RGX-104; RGX104; RGX 104;
SMILES	O=C(O)CC1=CC=CC(OCC[C@H](N(CC2=CC=CC(C(F)(F)F)=C2Cl)CC(C3=CC=CC=C3)C4=CC=CC=C4)C)=C1.[H]Cl
Chemical Name
Formula	C34H34Cl2F3NO3	M. Wt	632.54
Purity	98%	Storage	Store at 4-8°C
Description	RGX-104 is a liver X receptor beta agonist with potential immunomodulating and antineoplastic activities. Upon oral administration, RGX-104 selectively targets and binds to LXRbeta, thereby activating LXRbeta-mediated signaling, leading to the transcription of certain tumor suppressor genes and the downregulation of certain tumor promoter genes. This particularly activates the expression of apolipoprotein E (ApoE), a tumor suppressor protein, in tumor cells and certain immune cells. This activates the innate immune system, resulting in depletion of immunosuppressive myeloid-derived suppressor cells (MDSCs), tumor cells and endothelial cells in the tumor microenvironment. This reverses immune evasion, enhances anti-tumor immune responses and inhibits proliferation of tumor cells.