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Org 25543 hydrochloride Chemical Structure

Org 25543 hydrochloride

Data Sheet For research use only. Not for human use.
Cat. No. :BCP33172CAS No. :495076-64-7Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 495076-64-7 Cat. No. BCP33172
Name Org 25543 hydrochloride
Synonyms ORG25543 HCl; Org 25543 HCl;Org-25543 HCl;
SMILES CN(C)C1(CCCC1)CNC(=O)C2=CC(=C(C(=C2)OC)OCC3=CC=CC=C3)OC.Cl
Chemical Name
Formula C24H32lN2O4.HCl M. Wt 448.99
Purity 98% Storage Store at 4-8°C
Description Org 25543 hydrochloride is a potent and selective glycine transporter type 2 (GlyT2) inhibitor (IC50 = 16 nM for hGlyT2). Displays no activity at GlyT1 or 56 other common biological targets (≥ 100 μM), in a glycine uptake assay in CHO cells. Ameliorates mechanical allodynia after partial sciatic nerve ligation injury in mice.
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