Org 25543 hydrochloride New
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CAS No. | 495076-64-7 | Cat. No. | BCP33172 |
Name | Org 25543 hydrochloride | ||
Synonyms | ORG25543 HCl; Org 25543 HCl;Org-25543 HCl; | ||
SMILES | CN(C)C1(CCCC1)CNC(=O)C2=CC(=C(C(=C2)OC)OCC3=CC=CC=C3)OC.Cl | ||
Chemical Name | |||
Formula | C24H32lN2O4.HCl | M. Wt | 448.99 |
Purity | 98% | Storage | Store at 4-8°C |
Description | Org 25543 hydrochloride is a potent and selective glycine transporter type 2 (GlyT2) inhibitor (IC50 = 16 nM for hGlyT2). Displays no activity at GlyT1 or 56 other common biological targets (≥ 100 μM), in a glycine uptake assay in CHO cells. Ameliorates mechanical allodynia after partial sciatic nerve ligation injury in mice. |
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