Cyclophosphamide
Data Sheet
For research use only. Not for human use.
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| CAS No. | 50-18-0 | Cat. No. | BCP02139 |
| Name | Cyclophosphamide | ||
| Synonyms | Cyclophosphane; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C7H15Cl2N2O2P | M. Wt | 261.09 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Cyclophosphamide is an alkylating agent with cytotoxic and immunosuppressive activities. Cyclophosphamide requires enzymatic and chemical activation to release active phosphoramide mustard which produces the interstrand and intrastrand DNA crosslinks at guanine N-7 positions. Cyclophosphamide exerts its cytotoxic activity by inhibiting nuclear DNA replication. The mechanism of Cyclophosphamide -induced immunosuppression is possibly due to direct cytotoxic effect of the drug on immunocompetent lymphocytes, particulafly those that have undergone antigenic differentiation and division. Cyclophosphamide has its greatest effect on B cells with relative T cell-sparing effect. [1] Trials in various tumor-bearing animals confirmed this in vivo activity and demonstrated fairly potent antitumor effect. Cyclophosphamide, in combination with other antineoplastic agents, is used for the treatment of various cancers, including breast, lymphoid and pediatric malignancies. | ||
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