KU57788

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP01954CAS No. ：503468-95-9Purity：98%

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CAS No.	503468-95-9	Cat. No.	BCP01954
Name	KU57788
Synonyms	KU 57788;NU-7441;KU-57788;NU7441;NU 7441;
SMILES
Chemical Name
Formula	C25H19NO3S	M. Wt	413.49
Purity	98%	Storage	Store at 4-8°C
Description	NU7441 increases the persistence of γH2AX foci after ionizing radiation–induced or etoposide-induced DNA damage. NU7441 (0.5 μM or 1 μM) appreciably increases G2-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. NU7441 causes persistence of doxorubicin- and ionising radiation-induced DNA double-strand break and also slightly decreases homologous recombination activity DNA-PK-proficient M059-Fus-1 and DNA-PK-deficient M059 J human tumour cells. NU7441 inhibits UV-induced RPA p34 hyperphosphorylation in a dose-dependent manner both in cells lacking and cells expressing polymerase η. NU7441 increases levels of fludarabine-induced γH2AX foci and correspondingly decreased fludarabine-induced cell death in chronic lymphocytic leukemia cells. NU7441 also inhibits mitoxantrone-induced DNA-PKcs autophosphorylation and repair in chronic lymphocytic leukemia cells.