PI-103 Hydrochloride New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 371935-79-4 | Cat. No. | BCP36117 |
| Related Products | PI-103（PI-103 hydrobromide） 371935-74-9（PI-103） | ||
| Name | PI-103 Hydrochloride | ||
| Synonyms | PI103 Hydrochloride; PI-103 HCl; PI 103 Hydrochloride; | ||
| SMILES | C1COCCN1C2=NC(=NC3=C2OC4=C3C=CC=N4)C5=CC(=CC=C5)O.Cl | ||
| Chemical Name | |||
| Formula | C19H17ClN4O3 | M. Wt | 384.82 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of phosphatidylinositol 3-kinase (PI3K) family members with selectivity toward DNA-PK, PI3K (p110α), and mTOR.PI-103 Hydrochloride is a dual PI3K and mTOR inhibitor with IC50s of 8 nM, 88 nM, 48 nM, 150 nM, 20 nM, and 83 nM for p110α, p110β, p110δ, p110γ, mTORC1, and mTORC2. PI-103 Hydrochloride also inhibits DNA-PK with an IC50 of 2 nM. PI-103 Hydrochloride induces autophagy. | ||
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