Terfenadine New
Data Sheet
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| CAS No. | 50679-08-8 | Cat. No. | BCP43974 |
| Name | Terfenadine | ||
| Synonyms | BRN 5857899; BRN5857899; BRN-5857899; Seldane; Terfen; | ||
| SMILES | CC(C)(C)C1=CC=C(C=C1)C(CCCN2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)O | ||
| Chemical Name | |||
| Formula | C32H41NO2 | M. Wt | 471.67 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Terfenadine is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistaminic and non-sedative effects. Terfenadine's active metabolite competitively binds peripheral H1-receptors, thereby stabilizing an inactive conformation of the receptor. Consequently, usual allergic responses as a result of mast-cell degranulation followed by the release of multiple inflammatory mediators, such as interleukins, prostaglandins, and leukotriene precursors, are blocked, thereby preventing the triggering of pro-inflammatory pathways. | ||
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