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Tetrabenazine Chemical Structure

Tetrabenazine

Data Sheet For research use only. Not for human use.
Cat. No. :BCP15831CAS No. :58-46-8Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 58-46-8 Cat. No. BCP15831
Name Tetrabenazine
Synonyms Nitoman;Ro 1-9569;
SMILES CC(C)CC1CN2CCC3=CC(=C(C=C3C2CC1=O)OC)OC
Chemical Name
Formula C19H27NO3 M. Wt 317.42
Purity 98% Storage Store at 4-8°C
Description Tetrabenazine is a drug for the symptomatic treatment of hyperkinetic movement disorder. On August 15, 2008 the U.S. Food and Drug Administration (FDA) approved the use of tetrabenazine to treat chorea associated with Huntington's disease (HD), the first in the US. The precise mechanism of action of tetrabenazine is unknown. The antichorea effect is believed to be related to its effect as a reversible depletory of monoamines (such as dopamine, serotonin, norepinephrine and histamine)from nerve terminals) Tetrabenazine reversibly inhibits VMAT-2 resulting in decreased of monamines into synaptic vesicles
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