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Ozagrel Chemical Structure

Ozagrel

Data Sheet For research use only. Not for human use.
Cat. No. :BCP12147CAS No. :82571-53-7Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 82571-53-7 Cat. No. BCP12147
Name Ozagrel
Synonyms OKY046;OKY-046;OKY 046;
SMILES
Chemical Name
Formula C13H12N2O2 M. Wt 228.25
Purity 98% Storage Store at 4-8°C
Description Ozagrel was selected as the best compound of highly selective inhibitors of TXA2 synthase. The inhibition of TXA2 synthase by ozagrel was more effective on human and rabbit enzymes than those of other species. Ozagrel increased 6-keto-PGF1 alpha, one of stable metabolites of PGI2, in various isolated cells and tissues perhaps via accumulated PG endoperoxides resulted by the inhibition of TXA2 synthase . Ozagrel was estimated to be a reversible mixed-type inhibitor of diphenolase activity with the constants (K (S1), K (S2), K (i1), and K (i2)) determined to be 2.21, 3.89, 0.454, and 0.799 mM, repectively . Infusion of OKY-046 significantly inhibited pulmonary thromboxane B2 delivery, attenuated the early increase in pulmonary vascular resistance, and blocked the increase in systemic vascular resistance. In addition, OKY-046 blunted and delayed the decrease in cardiac output and maintained end-systolic pressure-diameter relation, +dp/dt, and lung lymph flow at baseline values .
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