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CAS No. | 82749-70-0 | Cat. No. | BCP30868 |
Name | DCPIB | ||
Synonyms | Dcpib;4-(2-butyl-6,7-dichlor-2-cyclopentyl-indan-1-on-5-yl) oxybutyric acid; | ||
SMILES | CCCCC1(CC2=CC(=C(C(=C2C1=O)Cl)Cl)OCCCC(=O)O)C3CCCC3 | ||
Chemical Name | |||
Formula | C22H28Cl2O4 | M. Wt | 427.36 |
Purity | 98% | Storage | Store at 4-8°C |
Description | DCPIB is a selective, reversible and potent inhibitor of volume-regulated anion channels (VRAC), voltage-dependently activates potassium channels TREK1 and TRAAK, inhibits TRESK, TASK1 and TASK3 (IC50s, 0.14, 0.95, 50.72 μM, respectively). DCPIB is also a selective blocker of swelling-induced chloride current (ICl,swell), with an IC50 of 4.1 μM in CPAE cells. |
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