Amlodipine

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP02420CAS No. ：88150-42-9Purity：98%

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CAS No.	88150-42-9	Cat. No.	BCP02420
Name	Amlodipine
Synonyms	Norvasc;Istin;Intervask;
SMILES
Chemical Name
Formula	C20H25ClN2O5	M. Wt	408.88
Purity	98%	Storage	Store at 4-8°C
Description	Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the movement of calcium ions into vascular smooth muscle cells and cardiac muscle cells. Experimental data suggest amlodipine binds to both dihydropyridine and nondihydropyridine binding sites. The contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels. Amlodipine inhibits calcium ion influx across cell membranes selectively, with a greater effect on vascular smooth muscle cells than on cardiac muscle cells. Negative inotropic effects, or decreased heart muscle contractility, can be detected in vitro, but such effects have not been seen in intact animals at therapeutic doses. Serum calcium concentration is not affected by amlodipine. Within the physiologic pH range, amlodipine is an ionized compound (pKa = 8.6), and its interaction with the calcium channe