Gemigliptin New
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| CAS No. | 911637-19-9 | Cat. No. | BCP40330 |
| Name | Gemigliptin | ||
| Synonyms | LC15-0444; LC150444; LC-150444; LC 150444; | ||
| SMILES | C1CC(CN(C1=O)CC(CC(=O)N2CCC3=C(C2)N=C(N=C3C(F)(F)F)C(F)(F)F)N)(F)F | ||
| Chemical Name | |||
| Formula | C18H19F8N5O2 | M. Wt | 489.36 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Gemigliptin, also known as LC15-0444, is a potent dipeptidyl peptidase-4 (DPP-4) inhibitor was approved in South Korea as an oral anti-hyperglycemic agent (anti-diabetic drug). Gemigliptin dose-dependently inhibited methylglyoxal-modified AGE-bovine serum albumin (BSA) formation (IC50=11.69 mM). AGE-collagen cross-linking assays showed that gemigliptin had a potent inhibitory effect (IC50=1.39 mM) on AGE-BSA cross-links to rat tail tendon collagen, and its activity was stronger than aminoguanidine (IC50=26.4 mM). | ||
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