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MK-4101 Chemical Structure

MK-4101

Data Sheet For research use only. Not for human use.
Cat. No. :BCP18385CAS No. :935273-79-3Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 935273-79-3 Cat. No. BCP18385
Name MK-4101
Synonyms MK4101;MK 4101;
SMILES
Chemical Name
Formula C24H24F5N5O M. Wt 493.47
Purity 98% Storage Store at 4-8°C
Description MK-4101 is a potent and selective inhibitor of the Hedgehog Pathway. MK-401 Is Highly Active against Medulloblastoma and Basal Cell Carcinoma. MK-4101 showed anti-tumor activity through the inhibition of proliferation and induction of extensive apoptosis in tumor cells. MK-4101 was highly efficacious against primary medulloblastoma and BCC developing in the cerebellum and skin of Ptch1(+/-) mice. MK-4101 targets the Hh pathway in tumor cells, showing the maximum inhibitory effect on Gli1 MK-4101 also induced deregulation of cell cycle and block of DNA replication in tumors.
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