MK-4101
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CAS No. | 935273-79-3 | Cat. No. | BCP18385 |
Name | MK-4101 | ||
Synonyms | MK4101;MK 4101; | ||
SMILES | |||
Chemical Name | |||
Formula | C24H24F5N5O | M. Wt | 493.47 |
Purity | 98% | Storage | Store at 4-8°C |
Description | MK-4101 is a potent and selective inhibitor of the Hedgehog Pathway. MK-401 Is Highly Active against Medulloblastoma and Basal Cell Carcinoma. MK-4101 showed anti-tumor activity through the inhibition of proliferation and induction of extensive apoptosis in tumor cells. MK-4101 was highly efficacious against primary medulloblastoma and BCC developing in the cerebellum and skin of Ptch1(+/-) mice. MK-4101 targets the Hh pathway in tumor cells, showing the maximum inhibitory effect on Gli1 MK-4101 also induced deregulation of cell cycle and block of DNA replication in tumors. |
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