PF-4136309
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1341224-83-6 | Cat. No. | BCP03515 |
| Name | PF-4136309 | ||
| Synonyms | PF 4136309; PF-4136309; PF04136309; PF4136309; PF-04136309; INCB8761; INCB 8761; INCB-8761; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C29H31F3N6O3 | M. Wt | 568.59 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | PF-4136309, also known as INCB8761, is an orally available human chemokine receptor 2 (CCR2) antagonist with potential immunomodulating and antineoplastic activities. Upon oral administration, CCR2 antagonist PF-04136309 specifically binds to CCR2 and prevents binding of the endothelium-derived chemokine ligand CLL2 (monocyte chemoattractant protein-1 or MCP1) to its receptor CCR2, which may result in inhibition of CCR2 activation and signal transduction. This may inhibit inflammatory processes as well as angiogenesis, tumor cell migration, and tumor cell proliferation. | ||
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