Maraviroc New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP01819CAS No. ：376348-65-1Purity：98%

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CAS No.	376348-65-1	Cat. No.	BCP01819
Name	Maraviroc
Synonyms	UK-427857;Celsentri;UK427857;UK 427857;
SMILES
Chemical Name
Formula	C29H41F2N5O	M. Wt	513.67
Purity	98%	Storage	Store at 4-8°C
Description	Maraviroc inhibits MIP-1β-stimulated γ-S-GTP binding to HEK-293 cell membranes, indicating its ability to inhibit chemokine-dependent stimulation of GDP-GTP exchange at the CCR5/G protein complex. Maraviroc also inhibits the downstream event of chemokine-induced intracellular calcium redistribution, with IC50s ranging from 7 to 30 nM obtained against MIP-1β, MIP-1α and RANTES. In the same experiments, Maraviroc does not trigger release of intracellular calcium at concentrations up to 10 μM, indicating that it is devoid of CCR5 agonist activity. Consistent with this, Maraviroc fails to induce CCR5 internalization. Maraviroc is active at low nanomolar concentrations against HIV-1 Ba-L. Maraviroc inhibits all 200 pseudotyped viruses with a geometric mean IC90 of 13.7 nM.