Vicriviroc maleate
Data Sheet
For research use only. Not for human use.
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| CAS No. | 599179-03-0 | Cat. No. | BCP25914 |
| Name | Vicriviroc maleate | ||
| Synonyms | SCH 417690; SCH-417690; SCH417690; SCH-D; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C28H38F3N5O2.C4H4O4 | M. Wt | 649.71 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Vicriviroc maleate is a CCR5 antagonist with IC50 of 0.91 nM in clinical development for the treatment of HIV-1.Vicriviroc, also known as SCH 417690 and SCH-D, is a potent, orally active and selective CCR5 entry inhibitor of HIV-1. Vicriviroc is effective at nanomolar concentrations, it can be administered once daily. Vicriviroc binds to a small hydrophobic pocket between the transmembrane helices near the extracellular surface of the CCR5 receptor. Binding to this pocket induces a conformational change of the extracellular segment of CCR5 and prevents binding of gp120 to the target cell, consequently preventing the virus from entering the target cell at all. | ||
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