Azvudine New
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CAS No. | 1011529-10-4 | Cat. No. | BCP34041 |
Name | Azvudine | ||
Synonyms | RO-0622;RO 0622;RO0622; | ||
SMILES | C1=CN(C(=O)N=C1N)C2C(C(C(O2)(CO)N=[N+]=[N-])O)F | ||
Chemical Name | |||
Formula | C9H11FN6O4 | M. Wt | 286.22 |
Purity | 98% | Storage | Store at 4-8°C |
Description | Azvudine is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM). Azvudine inhibits NRTI-resistant viral strains[1]. Azvudine is a click chemistry reagent, itcontains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups. |
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