PF-04457845
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1020315-31-4 | Cat. No. | BCP05805 |
| Name | PF-04457845 | ||
| Synonyms | JZP150;JZP 150;JZP-150;PF 04457845;PF04457845;PF-4457845;PF 4457845;PF4457845; | ||
| SMILES | C1CN(CCC1=CC2=CC(=CC=C2)OC3=NC=C(C=C3)C(F)(F)F)C(=O)NC4=NN=CC=C4 | ||
| Chemical Name | |||
| Formula | C23H20F3N5O2 | M. Wt | 455.43 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | PF-04457845 is an orally active, irreversible inhibitor of fatty acid amide hydrolase (FAAH; IC50 = 7.2 nM) that is selective against other serine hydrolases. It is a covalent inhibitor that carbamylates the active site serine nucleophile of FAAH. In a rat model of inflammatory pain, oral administration of 0.1 mg/kg PF-04457845 has been shown to reduce inflammatory pain with efficacy comparable to that of naproxen. | ||
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