JNJ42165279

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP16594CAS No. ：1346528-50-4Purity：98%

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CAS No.	1346528-50-4	Cat. No.	BCP16594
Name	JNJ42165279
Synonyms	JNJ-42165279;JNJ 42165279;
SMILES
Chemical Name
Formula	C18H17ClF2N4O3	M. Wt	410.8
Purity	98%	Storage	Store at 4-8°C
Description	JNJ-42165279 covalently inactivates the FAAH enzyme, but is highly selective with regard to other enzymes, ion channels, transporters, and receptors. JNJ-42165279 exhibits high selectivity against a panel of 50 receptors, enzymes, transporters, and ion-channels at 10 μM, at which concentration it does not produce >50% inhibition of binding to any of the targets. Fortunately, JNJ-42165279 also does not inhibit CYPS (1A2, 2C8, 2C9, 2C19, 2D6, 3A4) or hERG when tested at a 10 μM compound concentration. in vivo: JNJ-42165279 exhibits excellent ADME and pharmacodynamic properties as evidenced by its ability to block FAAH in the brain and periphery of rats and thereby cause an elevation of the concentrations of anandamide (AEA), oleoyl ethanolamide (OEA), and palmitoyl ethanolamide (PEA). The compound was also efficacious in the spinal nerve ligation (SNL) model of neuropathic pain. JNJ-42165279 exhibits relatively rapid clearance in the course of rat pharmacokinetic experiments, manifesting