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Ruxolitinib phosphate Chemical Structure

Ruxolitinib phosphate

Data Sheet For research use only. Not for human use.
Cat. No. :BCP02251CAS No. :1092939-17-7Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1092939-17-7 Cat. No. BCP02251
Related Products 941678-49-5(Ruxolitinib)
Name Ruxolitinib phosphate
Synonyms INCB-018424 phosphate;INCB 018424 phosphate;IINCB018424 phosphate;
SMILES C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3.OP(=O)(O)O
Chemical Name
Formula C17H21N6O4P M. Wt 404.36
Purity 98% Storage Store at 4-8°C
Description Ruxolitinib Phosphate is the phosphate salt form of ruxolitinib, an orally bioavailable Janus-associated kinase (JAK) inhibitor with potential antineoplastic and immunomodulating activities. Ruxolitinib specifically binds to and inhibits protein tyrosine kinases JAK 1 and 2, which may lead to a reduction in inflammation and an inhibition of cellular proliferation. The JAK-STAT (signal transducer and activator of transcription) pathway plays a key role in the signaling of many cytokines and growth factors and is involved in cellular proliferation, growth, hematopoiesis, and the immune response; JAK kinases may be upregulated in inflammatory diseases, myeloproliferative disorders, and various malignancies.
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