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CAS No. | 1092939-17-7 | Cat. No. | BCP02251 |
Related Products | 941678-49-5(Ruxolitinib) | ||
Name | Ruxolitinib phosphate | ||
Synonyms | INCB-018424 phosphate;INCB 018424 phosphate;IINCB018424 phosphate; | ||
SMILES | C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3.OP(=O)(O)O | ||
Chemical Name | |||
Formula | C17H21N6O4P | M. Wt | 404.36 |
Purity | 98% | Storage | Store at 4-8°C |
Description | Ruxolitinib Phosphate is the phosphate salt form of ruxolitinib, an orally bioavailable Janus-associated kinase (JAK) inhibitor with potential antineoplastic and immunomodulating activities. Ruxolitinib specifically binds to and inhibits protein tyrosine kinases JAK 1 and 2, which may lead to a reduction in inflammation and an inhibition of cellular proliferation. The JAK-STAT (signal transducer and activator of transcription) pathway plays a key role in the signaling of many cytokines and growth factors and is involved in cellular proliferation, growth, hematopoiesis, and the immune response; JAK kinases may be upregulated in inflammatory diseases, myeloproliferative disorders, and various malignancies. |
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