LY2562175 New
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For research use only. Not for human use.
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| CAS No. | 1103500-20-4 | Cat. No. | BCP33226 |
| Name | LY2562175 | ||
| Synonyms | LY 2562175; LY-2562175; | ||
| SMILES | CN C=C(C2=C1C=C(C=C2)N3CCC(CC3)OCC4=C( | ||
| Chemical Name | |||
| Formula | C28H27Cl2N3O4 | M. Wt | 540.44 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | LY2562175 is a potent and selective FXR agonist in vitro and has robust lipid modulating properties, lowering LDL and triglycerides while raising HDL in preclinical species. The preclinical ADME properties of LY2562175 were consistent with enabling once daily dosing in humans, and it was ultimately advanced to the clinic for evaluation in humans. LY2562175 promotes transcriptional activation of human FXR in a cell-based cotransfection assay with an EC50 of 193 nM (geometric mean). | ||
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