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(Z)-Guggulsterone Chemical Structure

(Z)-Guggulsterone

Data Sheet For research use only. Not for human use.
Cat. No. :BCP07472CAS No. :39025-23-5Purity:98%
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  • Publications Citing of Biochempartner's (Z)-Guggulsterone
  • Chemical Properties&Biological Activity
CAS No. 39025-23-5 Cat. No. BCP07472
Name (Z)-Guggulsterone
Synonyms Z-Guggulsterone;Guggulsterone Z;
SMILES C/C=C/1\C(=O)C[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C
Chemical Name
Formula C21H28O2 M. Wt 312.45
Purity 98% Storage Store at 4-8°C
Description Broad spectrum steroid receptor ligand; mineralocorticoid, progesterone and glucocorticoid receptor antagonist (Ki values are 37, 224 and 252 nM respectively) and weak androgen receptor agonist (Ki = 315 nM). Induces apoptosis in prostate cancer cells and inhibits angiogenesis via suppression of the VEGF-VEGFR2-Akt signaling pathway. Exhibits antilipidemic activity via antagonism of the farnesoid X receptor (FXR) and displays antiseptic, antirheumatic and anti-inflammatory activity in vivo.
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